MIEF1

Across TCGA pan-cancer cohorts, MIEF1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MIEF1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MIEF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIEF1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where MIEF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIEF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.859	<.001	12	view →
LIHC	All	III,IV	+0.771	<.001	9	view →
THCA	All	III,IV	−0.536	<.001	9	view →
STAD	Male	II,III,IV	+0.951	<.001	8	view →
CHOL	Male	All	+1.484	<.001	5	view →
LUSC	Male	II,III,IV	+0.701	<.001	5	view →
COAD	Male	II,III,IV	+0.294	.001	4	view →
BRCA	Female	All	−0.193	.001	4	view →
READ	All	III,IV	+0.680	.011	2	view →
BLCA	All	All	+0.381	.036	2	view →
PRAD	All	All	+0.239	.016	2	view →
KIRC	Female	All	+0.271	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MIEF1–HNSC

Open the HNSC breakdown →