MIEF1

Across TCGA cell cohorts, MIEF1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MIEF1-associated genes across cancer lineages are OR10G7, SCGB1C1, and OR4K2. Each is linked with MIEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIEF1-to-partner and partner-to-MIEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G7 grouped by MIEF1-low versus MIEF1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIEF1→partner) and Y-score (partner→MIEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR10G7 →	+0.013	+6.357	<.001	<.001	3	1
CNS	SCGB1C1 →	+0.284	+4.981	<.001	.008	3	1
BLOOD_Leukemia	OR4K2 →	+0.020	+3.969	<.001	.009	3	1
BLOOD_Leukemia	BPIFB6 →	+0.031	+3.969	<.001	.009	3	1
BLOOD_Leukemia	GOLGA6C →	+0.054	+4.256	<.001	.001	3	1
BLOOD_Leukemia	C2orf73 →	+0.038	+3.450	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

OR10G7 by MIEF1 expression — CNS

Explore this box plot interactively →