MIDN

Across TCGA patient cohorts, MIDN mutation is significantly associated with the RNA expression of many other genes, with 308 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIDN-associated genes across cancer lineages are IGHVIII-22-2, LINC02759, and RN7SL745P. Each is linked with MIDN in more than 1 cancer types. Because this analysis shows association rather than direction, both MIDN-to-partner and partner-to-MIDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHVIII-22-2 grouped by MIDN-low versus MIDN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIDN→partner) and Y-score (partner→MIDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGHVIII-22-2 →	+1.391	+5.542	<.001	<.001	3	2
BLCA	LINC02759 →	+0.099	+3.996	.002	.002	3	2
UCEC	RN7SL745P →	+0.301	+2.090	.002	.003	3	2
SKCM	TSPY24P →	+0.082	+5.328	.001	.003	3	2
SKCM	MIR1179 →	+0.306	+5.993	<.001	.001	3	2
BLCA	RNU6ATAC3P →	+0.274	+3.008	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 308 associations by consensus.

IGHVIII-22-2 by MIDN expression — COAD

Explore this box plot interactively →