MIDN

Across TCGA patient cohorts, MIDN mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIDN-associated genes across cancer lineages are Monocytes, CD8+ Tem, and NK cells. Each is linked with MIDN in more than 1 cancer types. Because this analysis shows association rather than direction, both MIDN-to-partner and partner-to-MIDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by MIDN-low versus MIDN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIDN→partner) and Y-score (partner→MIDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Monocytes →	+0.012	+5.225	<.001	.034	3	1
STAD	CD8+ Tem →	+0.008	+4.567	.025	.008	3	1
STAD	NK cells →	+0.008	+5.597	<.001	.002	3	1
UCEC	Adipocytes →	+0.025	+2.403	<.001	.004	3	1
UCEC	Plasma cells →	-0.019	-2.864	.033	.037	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Monocytes by MIDN expression — SKCM

Explore this box plot interactively →