MID2

Across TCGA cell cohorts, MID2 mutation is significantly associated with the RNA expression of many other genes, with 114 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MID2-associated genes across cancer lineages are KLHL40, GNGT1, and GPHA2. Each is linked with MID2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MID2-to-partner and partner-to-MID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by MID2-low versus MID2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MID2→partner) and Y-score (partner→MID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1
BLOOD_Leukemia	GNGT1 →	+0.055	+3.551	<.001	.009	3	1
BLOOD_Leukemia	GPHA2 →	+0.071	+3.944	.003	.006	3	1
BLOOD_Leukemia	TLX3 →	+1.530	+3.944	.001	.006	3	1
BLOOD_Leukemia	KRT6C →	+0.021	+4.037	<.001	.004	3	1
BLOOD_Leukemia	OBP2B →	+0.032	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

KLHL40 by MID2 expression — BLOOD_Lymphoma

Explore this box plot interactively →