MICOS10-NBL1

Across TCGA pan-cancer cohorts, MICOS10-NBL1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MICOS10-NBL1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MICOS10-NBL1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MICOS10-NBL1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and LUAD show a favorable association.

KIRC, STAD, and BRCA are the cancer types where MICOS10-NBL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.511	0.748	.002	53	view →
STAD	DFS	Quartile	II,III,IV	0.348	0.633	.002	36	view →
BRCA	DFS	Tertile	II,III,IV	0.912	0.959	.002	32	view →
ACC	OS	Tertile	II,III,IV	0.710	0.917	.002	23	view →
LIHC	OS	Tertile	II,III,IV	0.302	0.642	.002	21	view →
ESCA	OS	Quartile	All	0.732	0.377	.003	19	view →
SCLC	DFS	Median	III,IV	0.338	0.968	.024	18	view →
TGCT	OS	Tertile	II,III,IV	0.752	1.000	.019	18	view →
PAAD	OS	Quartile	All	0.502	0.727	.014	17	view →
UVM	OS	Median	III,IV	0.310	0.700	.013	12	view →
LUAD	DFS	Median	III,IV	0.731	0.547	.014	12	view →
MESO	DFS	Tertile	II,III,IV	0.315	0.600	.034	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MICOS10-NBL1–KIRC (DFS)

Open the KIRC breakdown →