MICOS10-NBL1

Across TCGA pan-cancer cohorts, MICOS10-NBL1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MICOS10-NBL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MICOS10-NBL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MICOS10-NBL1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRP, LIHC, and KICH are the cancer types where MICOS10-NBL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MICOS10-NBL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	+0.040	.004	6	view →
LIHC	All	All	+0.014	<.001	6	view →
KICH	Female	All	−0.049	<.001	5	view →
HNSC	All	III,IV	+0.045	.009	5	view →
STAD	Male	II,III,IV	+0.035	.025	3	view →
ESCA	All	II,III,IV	+0.025	.037	2	view →
BRCA	All	II,III,IV	+0.020	.023	2	view →
LUSC	Male	All	+0.022	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MICOS10-NBL1–KIRP

Open the KIRP breakdown →