MICALL2

Across TCGA cell cohorts, MICALL2 mutation is significantly associated with the mutation status of many other genes, with 4,215 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MICALL2-associated genes across cancer lineages are KCNQ5, CHD8, and NCKAP5L. Each is linked with MICALL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MICALL2-to-partner and partner-to-MICALL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNQ5 grouped by MICALL2-low versus MICALL2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICALL2→partner) and Y-score (partner→MICALL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KCNQ5 →	+5.502	+5.502	.003	.003	1	5
SOFT_TISSUE	CHD8 →	+5.502	+5.502	.003	.003	1	5
LARGE_INTESTINE	NCKAP5L →	+2.146	+2.321	.008	.008	1	5
LARGE_INTESTINE	POLE →	+1.757	+2.278	.008	.008	1	5
LUNG_NSCLC_LUAD	PREX2 →	+2.681	+2.906	.005	.005	1	4
LARGE_INTESTINE	MYCBP2 →	+1.632	+3.906	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,215 associations by consensus.

KCNQ5 by MICALL2 expression — SOFT_TISSUE

Explore this box plot interactively →