MICALCL

Across TCGA patient cohorts, MICALCL mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MICALCL-associated genes across cancer lineages are p38-MAPK_pT180_Y182, TFRC, and Caspase-7-cleavedD198. Each is linked with MICALCL in more than 1 cancer types. Because this analysis shows association rather than direction, both MICALCL-to-partner and partner-to-MICALCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by MICALCL-low versus MICALCL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICALCL→partner) and Y-score (partner→MICALCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.505	-1.752	.002	.014	3	2
UCEC	TFRC →	+0.727	+2.662	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.532	+2.720	.016	.003	3	2
UCEC	14-3-3_beta →	-0.075	-2.295	.046	.033	3	1
UCEC	eEF2 →	+0.389	+3.459	.003	.005	3	1
UCEC	FASN →	+0.417	+1.765	.004	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

p38-MAPK_pT180_Y182 by MICALCL expression — UCEC

Explore this box plot interactively →