MICALCL

Across TCGA pan-cancer cohorts, MICALCL RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MICALCL’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MICALCL RNA is repressed in tumor relative to normal tissue. In most cancer types MICALCL is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and HNSC are the cancer types where MICALCL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MICALCL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	−1.800	<.001	11	view →
COAD	Female	II,III,IV	−1.435	<.001	11	view →
HNSC	Male	All	+1.315	<.001	10	view →
BLCA	All	III,IV	+1.277	.005	8	view →
LUSC	Female	All	−1.895	<.001	6	view →
BRCA	All	III,IV	+0.993	<.001	6	view →
KIRP	Female	All	+0.437	.011	6	view →
STAD	All	II,III,IV	+0.612	.003	5	view →
UCEC	All	All	+0.537	.006	4	view →
KIRC	Male	All	+0.252	<.001	3	view →
PAAD	All	All	+1.172	.009	2	view →
READ	All	All	−1.140	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MICALCL–LUAD

Open the LUAD breakdown →