MICALCL

Across TCGA cell cohorts, MICALCL mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MICALCL-associated genes across cancer lineages are NPFFR1, GPR101, and PRND. Each is linked with MICALCL in more than 1 cancer types. Because this analysis shows association rather than direction, both MICALCL-to-partner and partner-to-MICALCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPFFR1 grouped by MICALCL-low versus MICALCL-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICALCL→partner) and Y-score (partner→MICALCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NPFFR1 →	+0.014	+4.359	<.001	<.001	3	1
BLOOD_Leukemia	GPR101 →	+0.112	+3.966	<.001	.001	3	1
BLOOD_Leukemia	PRND →	+0.007	+3.289	<.001	.009	3	1
BLOOD_Leukemia	FOXS1 →	+0.057	+3.949	.001	.002	3	1
BLOOD_Leukemia	NKX2-6 →	+0.337	+4.201	<.001	.001	3	1
BLOOD_Leukemia	MBD3L3 →	+0.018	+3.289	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

NPFFR1 by MICALCL expression — BLOOD_Leukemia

Explore this box plot interactively →