MICAL3

Across TCGA patient cohorts, MICAL3 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MICAL3-associated genes across cancer lineages are 4E-BP1, eIF4E, and Notch1. Each is linked with MICAL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MICAL3-to-partner and partner-to-MICAL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MICAL3-low versus MICAL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MICAL3→partner) and Y-score (partner→MICAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.209	+1.999	.005	.008	3	3
COAD	eIF4E →	+0.177	+1.900	.018	.030	2	3
UCEC	Notch1 →	+0.113	+1.273	.004	.007	3	2
UCEC	PRAS40_pT246 →	+0.098	+1.222	.043	.032	3	2
UCEC	Rad50 →	-0.239	-1.447	<.001	.002	3	2
UCEC	ATM →	-0.556	-1.632	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

4E-BP1 by MICAL3 expression — UCEC

Explore this box plot interactively →