MIA3

Across TCGA patient cohorts, MIA3 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MIA3-associated genes across cancer lineages are ATM, 4E-BP1, and eIF4E. Each is linked with MIA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both MIA3-to-partner and partner-to-MIA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MIA3-low versus MIA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIA3→partner) and Y-score (partner→MIA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.488	-1.447	<.001	.002	3	4
COAD	4E-BP1 →	+0.243	+1.882	.008	.031	3	4
STAD	eIF4E →	+0.168	+3.321	.048	.010	3	3
SKCM	TIGAR →	+0.192	+3.012	.009	.018	3	3
COAD	TAZ →	+0.172	+2.610	.037	.005	3	3
COAD	ASNS →	+0.549	+2.321	<.001	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

ATM by MIA3 expression — UCEC

Explore this box plot interactively →