MIA3

Across TCGA pan-cancer cohorts, MIA3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MIA3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MIA3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MIA3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where MIA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.343	<.001	11	view →
THCA	Male	III,IV	−1.029	<.001	10	view →
HNSC	All	III,IV	+0.658	<.001	9	view →
BRCA	All	II,III,IV	+0.420	<.001	6	view →
KICH	Female	All	−1.126	<.001	5	view →
LIHC	Male	All	+0.678	<.001	5	view →
LUAD	All	All	+0.484	<.001	5	view →
STAD	Male	II,III,IV	+0.538	.004	3	view →
BLCA	Female	All	+0.486	.015	3	view →
PRAD	All	All	+0.861	<.001	2	view →
COAD	Female	All	−0.678	.001	2	view →
KIRP	All	II,III,IV	+0.448	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MIA3–KIRC

Open the KIRC breakdown →