MIA3

Across TCGA cell cohorts, MIA3 mutation is significantly associated with the RNA expression of many other genes, with 1,607 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIA3-associated genes across cancer lineages are IL5RA, C6, and FAM205A. Each is linked with MIA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MIA3-to-partner and partner-to-MIA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL5RA grouped by MIA3-low versus MIA3-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIA3→partner) and Y-score (partner→MIA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IL5RA →	+0.034	+4.321	<.001	.001	3	2
LUNG_NSCLC_LUSC	C6 →	+0.057	+3.925	<.001	.002	3	2
OVARY	FAM205A →	+0.054	+3.866	<.001	.002	3	2
OESOPHAGUS	NXPH2 →	+0.020	+4.017	<.001	.007	3	1
OESOPHAGUS	OR8B12 →	+0.061	+4.392	<.001	.003	3	1
LUNG_NSCLC_LUAD	GPR42 →	+0.016	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,607 associations by consensus.

IL5RA by MIA3 expression — URINARY_TRACT

Explore this box plot interactively →