MIA3

Across TCGA cell cohorts, MIA3 mutation is significantly associated with the mutation status of many other genes, with 6,048 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MIA3-associated genes across cancer lineages are MAP1B, FAT4, and DYNC1H1. Each is linked with MIA3 in more than 6 cancer types. Because this analysis shows association rather than direction, both MIA3-to-partner and partner-to-MIA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP1B grouped by MIA3-low versus MIA3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MIA3→partner) and Y-score (partner→MIA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAP1B →	+1.459	+1.743	.003	.003	1	7
BLOOD_Lymphoma	FAT4 →	+1.517	+2.514	.005	.005	1	6
LARGE_INTESTINE	DYNC1H1 →	+2.032	+3.145	<.001	<.001	1	6
LARGE_INTESTINE	SLC4A8 →	+3.584	+2.310	<.001	<.001	1	5
LUNG_NSCLC_LUAD	GPR158 →	+2.830	+4.469	.001	.001	1	5
UPPER_AERODIGESTIVE_TRACT	ABCA2 →	+2.954	+4.247	.006	.006	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,048 associations by consensus.

MAP1B by MIA3 expression — LARGE_INTESTINE

Explore this box plot interactively →