MIA-RAB4B

Across TCGA pan-cancer cohorts, MIA-RAB4B RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MIA-RAB4B’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where MIA-RAB4B RNA is repressed in tumor relative to normal tissue. In most cancer types MIA-RAB4B is over-expressed in tumor, although a few such as BRCA and HNSC show the opposite, repressed pattern.

BRCA, STAD, and LUSC are the cancer types where MIA-RAB4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MIA-RAB4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	−0.140	<.001	6	view →
STAD	Male	All	+0.073	.029	4	view →
LUSC	All	All	+0.052	.007	2	view →
HNSC	All	II,III,IV	−0.039	.015	2	view →
COAD	Female	III,IV	−0.034	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MIA-RAB4B–BRCA

Open the BRCA breakdown →