MGRN1

Across TCGA pan-cancer cohorts, MGRN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MGRN1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MGRN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MGRN1 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

LUAD, GBM, and LSCC are the cancer types where MGRN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.498	0.816	<.001	20	view →
GBM	DFS	Quartile	All	0.491	0.221	.004	8	view →
LSCC	DFS	Tertile	II,III,IV	0.480	0.746	.039	4	view →
PDAC	OS	Median	III,IV	0.755	0.160	.047	4	view →
CCRCC	DFS	Median	All	0.863	0.747	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MGRN1–LUAD (DFS)

Open the LUAD breakdown →