MGAT4C

Across TCGA patient cohorts, MGAT4C mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGAT4C-associated genes across cancer lineages are Cyclin-E1, ACC1, and PKC-a_pS657. Each is linked with MGAT4C in more than 2 cancer types. Because this analysis shows association rather than direction, both MGAT4C-to-partner and partner-to-MGAT4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E1 grouped by MGAT4C-low versus MGAT4C-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAT4C→partner) and Y-score (partner→MGAT4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-E1 →	+0.263	+2.321	.032	.035	3	3
UCEC	ACC1 →	+0.285	+2.335	.036	.018	3	3
LUAD	PKC-a_pS657 →	-0.355	-2.966	.018	.034	3	2
UCEC	EGFR →	-0.194	-2.700	.001	.006	3	2
UCEC	p62 Lck ligand →	+0.351	+2.817	.004	.001	3	2
UCEC	Tuberin_pT1462 →	+0.220	+1.765	.011	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Cyclin-E1 by MGAT4C expression — LUAD

Explore this box plot interactively →