MGAT4C

Across TCGA pan-cancer cohorts, MGAT4C RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MGAT4C data layer compared with 8 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MGAT4C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MGAT4C expression acts as an unfavorable survival marker, although some lineages such as LGG and LIHC show a favorable association.

KIRP, BLCA, and ACC are the cancer types where MGAT4C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.327	0.795	<.001	128	view →
BLCA	DFS	Quartile	III,IV	0.147	0.351	.001	87	view →
ACC	OS	Tertile	II,III,IV	0.311	0.735	<.001	81	view →
UCEC	DFS	Tertile	All	0.561	0.673	<.001	66	view →
LGG	DFS	Median	All	0.513	0.274	<.001	54	view →
READ	DFS	Tertile	All	0.571	0.876	<.001	48	view →
LIHC	OS	Tertile	All	0.681	0.457	.005	30	view →
HNSC	OS	Median	All	0.633	0.773	.004	20	view →
BRCA	OS	Quartile	II,III,IV	0.922	0.966	.008	19	view →
PAAD	DFS	Median	All	0.368	0.215	.003	17	view →
KICH	OS	Quartile	III,IV	0.297	0.935	<.001	13	view →
SCLC	OS	Median	II,III,IV	0.747	0.519	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MGAT4C–KIRP (OS)

Open the KIRP breakdown →