MGAT1

Across TCGA patient cohorts, MGAT1 mutation is significantly associated with the RNA expression of many other genes, with 1,905 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGAT1-associated genes across cancer lineages are AOC2, ARHGAP11A, and OR9Q2. Each is linked with MGAT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MGAT1-to-partner and partner-to-MGAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AOC2 grouped by MGAT1-low versus MGAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAT1→partner) and Y-score (partner→MGAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AOC2 →	+0.871	+3.700	<.001	.001	3	3
UCEC	ARHGAP11A →	+0.677	+3.700	.002	.001	3	3
BLCA	OR9Q2 →	+0.016	+4.722	<.001	.003	3	3
LGG	OR4G2P →	+0.059	+7.977	<.001	.007	3	2
BLCA	RPL7P55 →	+0.032	+3.592	.003	.004	3	2
BLCA	DANT1 →	+1.700	+3.360	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,905 associations by consensus.

AOC2 by MGAT1 expression — UCEC

Explore this box plot interactively →