Q-omics provides the consensus-scored DANT1 profile across patient tissues and cancer cell-line models. DANT1 expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in COAD. Among the 18 cancer types available for tumor–normal comparison, DANT1 is differentially expressed in 4, with the highest sampling consensus in HNSC. Additionally, DANT1 RNA expression shows 9,256 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight COAD, HNSC, and TGCT as cancer lineages where DANT1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for DANT1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes DANT1 survival associations across molecular data types. DANT1 RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible DANT1 RNA expression–survival associations across cancer types. High DANT1 expression shows unfavorable associations in COAD, ACC, LIHC and KIRC, but favorable associations in THCA and LUAD. The COAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify COAD as the clearest survival context for DANT1 RNA expression.
This table summarizes DANT1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for DANT1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. DANT1 shows lower tumor expression in THCA and KIRP and higher tumor expression in HNSC and LUSC. The HNSC box plot shows higher DANT1 RNA expression in tumor versus normal tissue (log2 FC = +0.277, t-test p = .020).
This table shows molecular features associated with DANT1 in patient tissues and cancer cell lines. In patient samples, DANT1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
