MGAM2

Across TCGA patient cohorts, MGAM2 mutation is significantly associated with the RNA expression of many other genes, with 6,061 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGAM2-associated genes across cancer lineages are RPL21P66, RN7SL822P, and OR5AC2. Each is linked with MGAM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MGAM2-to-partner and partner-to-MGAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL21P66 grouped by MGAM2-low versus MGAM2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAM2→partner) and Y-score (partner→MGAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RPL21P66 →	+0.079	+4.175	<.001	<.001	3	3
LUSC	RN7SL822P →	+0.151	+4.548	<.001	.009	3	3
SARC	OR5AC2 →	+0.064	+6.152	<.001	.001	3	2
SARC	DNAJA1P1 →	+0.056	+5.477	<.001	.004	3	2
SARC	RPS20P25 →	+0.176	+5.620	<.001	.004	3	2
SARC	UBE2V1P9 →	+0.170	+5.620	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,061 associations by consensus.

RPL21P66 by MGAM2 expression — CESC

Explore this box plot interactively →