MGAM2

Across TCGA pan-cancer cohorts, MGAM2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MGAM2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MGAM2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MGAM2 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KIRC, KICH, and STAD are the cancer types where MGAM2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MGAM2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+0.578	<.001	10	view →
KICH	All	II,III,IV	−0.140	<.001	10	view →
STAD	All	II,III,IV	+2.129	.001	7	view →
HNSC	All	II,III,IV	−0.714	.001	7	view →
BRCA	All	III,IV	−1.943	<.001	6	view →
CHOL	All	All	+1.060	.006	4	view →
ESCA	All	All	+3.255	.014	3	view →
LUSC	All	All	+0.417	.006	2	view →
LIHC	Female	All	+0.204	.027	2	view →
THCA	Female	All	−0.067	<.001	2	view →
COAD	Female	All	−0.903	.017	1	view →
KIRP	Female	All	−0.122	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MGAM2–KIRC

Open the KIRC breakdown →