MGAM

Across TCGA pan-cancer cohorts, MGAM mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MGAM data layer compared with 24 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MGAM mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MGAM expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, HNSC, and GBM are the cancer types where MGAM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	III,IV	0.218	0.743	.007	7	view →
HNSC	OS	Tertile	IV	0.905	0.632	.024	3	view →
GBM	OS	Tertile	All	0.257	0.546	.026	2	view →
PDAC	OS	Median	III,IV	0.518	1.000	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MGAM–LUAD (OS)

Open the LUAD breakdown →