MGAM

Across TCGA patient cohorts, MGAM protein abundance is significantly associated with the RNA expression of many other genes, with 7,949 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible MGAM-associated genes across cancer lineages are ADGRG3, CXCL1, and CXCL8. Each is linked with MGAM in more than 5 cancer types. Because this analysis shows association rather than direction, both MGAM-to-partner and partner-to-MGAM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MGAM versus ADGRG3 in COAD, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAM→partner) and Y-score (partner→MGAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ADGRG3 →	+1.208	+0.859	.003	.008	3	6
UCEC	CXCL1 →	+2.296	+0.715	<.001	<.001	3	6
GBM	CXCL8 →	+2.107	+0.994	<.001	<.001	3	6
GBM	AQP9 →	+1.739	+1.273	<.001	<.001	3	5
LSCC	S100A12 →	+1.915	+0.826	<.001	<.001	3	5
HNSC	PROK2 →	+0.903	+0.629	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,949 associations by consensus.

MGAM vs ADGRG3 — COAD

Explore this scatter interactively →