MGAM

Across TCGA patient cohorts, MGAM mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGAM-associated genes across cancer lineages are Src, ASNS, and FOXO3a_pS318_S321. Each is linked with MGAM in more than 4 cancer types. Because this analysis shows association rather than direction, both MGAM-to-partner and partner-to-MGAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src grouped by MGAM-low versus MGAM-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAM→partner) and Y-score (partner→MGAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Src →	-0.161	-1.354	.009	.035	3	5
COAD	ASNS →	+0.526	+2.000	<.001	.007	3	4
LUAD	FOXO3a_pS318_S321 →	-0.092	-2.305	.005	.004	3	3
BRCA	JNK_pT183_Y185 →	-0.273	-2.321	.015	.037	3	3
BRCA	p27_pT198 →	+0.151	+3.459	.049	.006	3	3
BRCA	S6_pS240_S244 →	+0.498	+2.817	.014	.037	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

Src by MGAM expression — COAD

Explore this box plot interactively →