MGAM

Across TCGA cell cohorts, MGAM mutation is significantly associated with the RNA expression of many other genes, with 1,391 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MGAM-associated genes across cancer lineages are NEMP2, OR4X2, and MRPL48. Each is linked with MGAM in more than 2 cancer types. Because this analysis shows association rather than direction, both MGAM-to-partner and partner-to-MGAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEMP2 grouped by MGAM-low versus MGAM-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGAM→partner) and Y-score (partner→MGAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NEMP2 →	+0.763	+3.199	.005	.007	3	3
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	2
SKIN	MRPL48 →	+0.429	+2.000	<.001	.009	3	2
BLOOD_Leukemia	PHOX2B →	+0.010	+2.381	.009	.008	3	2
BLOOD_Leukemia	GPR63 →	+1.043	+3.199	.002	.007	3	2
BLOOD_Leukemia	TCF21 →	+0.008	+2.536	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,391 associations by consensus.

NEMP2 by MGAM expression — BLOOD_Leukemia

Explore this box plot interactively →