MGA

Across TCGA patient cohorts, MGA protein abundance is significantly associated with the RNA expression of many other genes, with 15,612 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MGA-associated genes across cancer lineages are POLE2, VRK1, and CSE1L. Each is linked with MGA in more than 4 cancer types. Because this analysis shows association rather than direction, both MGA-to-partner and partner-to-MGA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MGA versus POLE2 in LSCC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGA→partner) and Y-score (partner→MGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POLE2 →	+1.140	+0.409	<.001	<.001	3	5
LSCC	VRK1 →	+0.802	+0.284	<.001	<.001	3	5
LSCC	CSE1L →	+0.598	+0.233	<.001	<.001	3	5
BRCA	XPO5 →	+0.806	+0.289	<.001	<.001	3	5
GBM	LRR1 →	+0.616	+0.279	<.001	.002	3	5
LSCC	POLR1C →	+0.723	+0.295	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,612 associations by consensus.

MGA vs POLE2 — LSCC

Explore this scatter interactively →