MGA

Across TCGA patient cohorts, MGA mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MGA-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and C-Raf. Each is linked with MGA in more than 4 cancer types. Because this analysis shows association rather than direction, both MGA-to-partner and partner-to-MGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MGA-low versus MGA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGA→partner) and Y-score (partner→MGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.175	+2.230	<.001	.006	3	5
UCEC	ASNS →	+0.332	+1.447	<.001	.002	3	4
BLCA	C-Raf →	+0.179	+1.754	.009	.047	3	4
COAD	FASN →	+0.386	+1.708	.009	.026	3	4
CESC	CD49b →	+0.332	+3.000	.016	.033	3	3
STAD	Lck →	+0.425	+2.459	<.001	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Caspase-7-cleavedD198 by MGA expression — COAD

Explore this box plot interactively →