MGA

Across TCGA cell cohorts, MGA mutation is significantly associated with the RNA expression of many other genes, with 638 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MGA-associated genes across cancer lineages are GAD2, GYS2, and OR10Q1. Each is linked with MGA in more than 2 cancer types. Because this analysis shows association rather than direction, both MGA-to-partner and partner-to-MGA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAD2 grouped by MGA-low versus MGA-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MGA→partner) and Y-score (partner→MGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GAD2 →	+0.027	+2.874	.001	.008	3	2
PANCREAS	GYS2 →	+0.108	+4.237	.002	.006	3	2
PANCREAS	OR10Q1 →	+0.025	+4.614	<.001	.004	3	2
PANCREAS	UGT2B11 →	+0.239	+4.011	<.001	.009	3	2
PANCREAS	OTC →	+1.340	+4.491	<.001	.003	3	2
LUNG_NSCLC_LUAD	AMN →	+1.466	+3.206	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 638 associations by consensus.

GAD2 by MGA expression — SOFT_TISSUE

Explore this box plot interactively →