MFSD5

Across TCGA patient cohorts, MFSD5 mutation is significantly associated with the RNA expression of many other genes, with 1,207 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFSD5-associated genes across cancer lineages are HSFY2, RPS4XP15, and BNIP3P41. Each is linked with MFSD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD5-to-partner and partner-to-MFSD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY2 grouped by MFSD5-low versus MFSD5-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD5→partner) and Y-score (partner→MFSD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	HSFY2 →	+0.015	+5.108	<.001	.008	3	2
LIHC	RPS4XP15 →	+0.067	+5.878	<.001	.002	3	2
UCEC	BNIP3P41 →	+0.014	+4.571	<.001	.002	3	2
UCEC	MIR6803 →	+0.161	+4.571	<.001	.002	3	2
SKCM	RAB28P2 →	+0.039	+4.302	.003	.007	3	2
SKCM	CCDC39-AS1 →	+0.347	+4.637	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,207 associations by consensus.

HSFY2 by MFSD5 expression — LIHC

Explore this box plot interactively →