MFSD5

Across TCGA pan-cancer cohorts, MFSD5 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MFSD5 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MFSD5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MFSD5 expression acts as an unfavorable survival marker, although some lineages such as THCA and COAD show a favorable association.

LUAD, LIHC, and MESO are the cancer types where MFSD5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.309	0.487	<.001	87	view →
LIHC	OS	Median	All	0.612	0.758	<.001	83	view →
MESO	OS	Tertile	II,III,IV	0.448	0.725	<.001	69	view →
KIRP	OS	Quartile	All	0.310	0.870	.001	54	view →
LGG	OS	Median	All	0.742	0.878	<.001	44	view →
UVM	DFS	Median	All	0.441	0.711	.002	42	view →
UCS	DFS	Median	IV	0.367	0.952	.001	36	view →
HNSC	DFS	Quartile	IV	0.436	0.804	.004	28	view →
LAML	DFS	Median	All	0.255	0.485	<.001	26	view →
READ	OS	Quartile	All	0.652	0.909	.008	26	view →
SKCM	OS	Median	All	0.263	0.404	<.001	24	view →
THCA	OS	Median	III,IV	0.988	0.755	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MFSD5–LUAD (DFS)

Open the LUAD breakdown →