MFSD5

Across TCGA patient cohorts, MFSD5 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFSD5-associated genes across cancer lineages are JNK2, ASNS, and EGFR_pY1068. Each is linked with MFSD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD5-to-partner and partner-to-MFSD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by MFSD5-low versus MFSD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD5→partner) and Y-score (partner→MFSD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.250	+2.000	.005	.032	3	2
UCEC	ASNS →	+0.507	+3.321	.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.272	-2.000	.016	.032	3	1
UCEC	ERK2 →	+0.204	+2.700	.018	.006	3	1
UCEC	ACC1 →	+0.350	+3.013	.032	.018	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.569	+2.179	.013	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

JNK2 by MFSD5 expression — UCEC

Explore this box plot interactively →