MFSD5

Across TCGA cell cohorts, MFSD5 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MFSD5-associated genes across cancer lineages are TMCO5A, FOXF2, and HUNK. Each is linked with MFSD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD5-to-partner and partner-to-MFSD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO5A grouped by MFSD5-low versus MFSD5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD5→partner) and Y-score (partner→MFSD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
BLOOD_Leukemia	FOXF2 →	+0.419	+3.829	<.001	.001	3	1
BLOOD_Leukemia	HUNK →	+1.193	+3.459	<.001	.006	3	1
BLOOD_Leukemia	STPG2 →	+0.122	+3.257	<.001	.009	3	1
BLOOD_Leukemia	SNTN →	+0.018	+3.185	.004	.006	3	1
BLOOD_Leukemia	TXNDC8 →	+0.006	+3.984	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

TMCO5A by MFSD5 expression — LARGE_INTESTINE

Explore this box plot interactively →