MFSD4B

Across TCGA pan-cancer cohorts, MFSD4B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MFSD4B data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MFSD4B mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MFSD4B expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, LSCC, and CCRCC are the cancer types where MFSD4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	III,IV	0.834	0.232	.024	10	view →
LSCC	OS	Median	All	0.791	0.926	.009	8	view →
CCRCC	DFS	Median	All	0.607	0.812	.026	4	view →
PDAC	OS	Median	II,III,IV	0.794	0.212	.024	3	view →
LUAD	OS	Tertile	All	0.893	0.640	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MFSD4B–UCEC (OS)

Open the UCEC breakdown →