MFSD4B

Across TCGA pan-cancer cohorts, MFSD4B mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MFSD4B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where MFSD4B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MFSD4B is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

LSCC, PDAC, and HNSC are the cancer types where MFSD4B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MFSD4B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.491	<.001	7	view →
PDAC	Female	All	−0.990	<.001	6	view →
HNSC	All	II,III,IV	−0.384	.005	6	view →
LUAD	All	All	+0.289	<.001	5	view →
CCRCC	All	All	−0.158	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MFSD4B–LSCC

Open the LSCC breakdown →