MFSD4A

Across TCGA patient cohorts, MFSD4A mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFSD4A-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Kit, and eEF2. Each is linked with MFSD4A in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD4A-to-partner and partner-to-MFSD4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MFSD4A-low versus MFSD4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD4A→partner) and Y-score (partner→MFSD4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.786	+2.502	<.001	.002	3	2
UCEC	c-Kit →	-0.197	-3.439	.031	.005	3	2
UCEC	eEF2 →	+0.336	+2.000	.016	.030	3	1
UCEC	EGFR_pY1068 →	-0.194	-2.584	.049	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.167	-2.584	.011	.010	3	1
UCEC	JNK2 →	+0.211	+2.502	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by MFSD4A expression — UCEC

Explore this box plot interactively →