MFSD4A

Across TCGA pan-cancer cohorts, MFSD4A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MFSD4A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MFSD4A RNA is repressed in tumor relative to normal tissue. In most cancer types MFSD4A is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where MFSD4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MFSD4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−4.526	<.001	12	view →
KIRP	Male	III,IV	−4.564	<.001	11	view →
KICH	Male	IV	−6.526	<.001	10	view →
LUSC	All	III,IV	−2.388	<.001	9	view →
COAD	Male	II,III,IV	−1.581	<.001	9	view →
THCA	Male	All	+0.862	<.001	9	view →
BRCA	All	III,IV	−1.493	<.001	6	view →
READ	All	All	−2.761	<.001	5	view →
STAD	All	IV	−4.120	.002	4	view →
HNSC	Male	All	−0.811	.030	4	view →
CHOL	All	All	+1.964	<.001	3	view →
LIHC	All	All	+0.231	.012	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MFSD4A–KIRC

Open the KIRC breakdown →