MFSD4A

Across TCGA cell cohorts, MFSD4A mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. CNS shows the largest number of these associations.

The most reproducible MFSD4A-associated genes across cancer lineages are TMCO5A, LINC02881, and SPO11. Each is linked with MFSD4A in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD4A-to-partner and partner-to-MFSD4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMCO5A grouped by MFSD4A-low versus MFSD4A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD4A→partner) and Y-score (partner→MFSD4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMCO5A →	+0.027	+4.415	<.001	.007	3	1
LARGE_INTESTINE	LINC02881 →	+0.013	+4.415	.005	.007	3	1
LARGE_INTESTINE	SPO11 →	+0.017	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
CNS	CLEC10A →	+0.161	+4.472	<.001	.004	3	1
CNS	BSPH1 →	+0.391	+4.643	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

TMCO5A by MFSD4A expression — LARGE_INTESTINE

Explore this box plot interactively →