MFSD14A

Across TCGA cell cohorts, MFSD14A mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MFSD14A-associated genes across cancer lineages are IL31, OR4C12, and ACR. Each is linked with MFSD14A in more than 1 cancer types. Because this analysis shows association rather than direction, both MFSD14A-to-partner and partner-to-MFSD14A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL31 grouped by MFSD14A-low versus MFSD14A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFSD14A→partner) and Y-score (partner→MFSD14A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IL31 →	+0.032	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.019	+5.662	<.001	.002	3	1
LARGE_INTESTINE	ACR →	+0.237	+3.212	.003	.006	3	1
LARGE_INTESTINE	TRMT1 →	+0.510	+3.212	.005	.006	3	1
LARGE_INTESTINE	PMP22 →	+1.673	+3.212	.001	.006	3	1
LARGE_INTESTINE	RARS1 →	+0.470	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

IL31 by MFSD14A expression — SKIN

Explore this box plot interactively →