MFSD14A

Across TCGA pan-cancer cohorts, MFSD14A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MFSD14A data layer compared with 4 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher MFSD14A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MFSD14A expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

SCLC, LIHC, and LGG are the cancer types where MFSD14A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	All	0.494	0.748	<.001	56	view →
LIHC	OS	Median	All	0.704	0.858	<.001	55	view →
LGG	OS	Median	All	0.371	0.527	<.001	54	view →
ACC	DFS	Tertile	All	0.157	0.644	<.001	48	view →
KIRC	OS	Median	All	0.710	0.547	<.001	38	view →
HNSC	OS	Quartile	All	0.493	0.821	.001	35	view →
COAD	OS	Median	All	0.854	0.750	.007	27	view →
KICH	DFS	Median	III,IV	0.318	0.901	.004	22	view →
PAAD	OS	Quartile	All	0.300	0.570	.008	18	view →
THYM	DFS	Median	All	0.936	0.797	.005	14	view →
READ	OS	Tertile	II,III,IV	0.922	0.393	.030	12	view →
UCS	DFS	Tertile	IV	0.956	0.381	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MFSD14A–SCLC (DFS)

Open the SCLC breakdown →