Across TCGA pan-cancer cohorts, MFSD13A mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MFSD13A’s most consistent transcriptional readouts.
The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MFSD13A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MFSD13A is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.
CCRCC, LUAD, and LSCC are the cancer types where MFSD13A tumor–normal differential expression is most reproducible.