MFRP

Across TCGA pan-cancer cohorts, MFRP Mutation is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated MFRP data layer compared with 3 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher MFRP Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MFRP expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

KICH, KIRC, and UCEC are the cancer types where MFRP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
KIRC	OS	Median	All	0.125	0.881	<.001	12	view →
UCEC	DFS	Median	II,III,IV	0.924	0.480	.031	10	view →
LUAD	DFS	Median	All	1.000	0.328	.028	7	view →
READ	DFS	Median	All	0.111	0.799	.001	6	view →
BLCA	DFS	Median	III,IV	0.778	0.271	.042	1	view →
COAD	OS	Median	II,III,IV	0.436	0.853	.013	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MFRP–KICH (DFS)

Open the KICH breakdown →