MFRP

Across TCGA patient cohorts, MFRP mutation is significantly associated with the RNA expression of many other genes, with 1,431 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFRP-associated genes across cancer lineages are NDUFA6, RTN4IP1, and FDFT1. Each is linked with MFRP in more than 2 cancer types. Because this analysis shows association rather than direction, both MFRP-to-partner and partner-to-MFRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFA6 grouped by MFRP-low versus MFRP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFRP→partner) and Y-score (partner→MFRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFA6 →	+0.440	+2.954	<.001	<.001	3	3
UCEC	RTN4IP1 →	+0.355	+3.584	.004	.002	3	3
UCEC	FDFT1 →	+0.737	+2.243	<.001	.005	3	3
CESC	PNPT1P2 →	+0.026	+4.891	<.001	<.001	3	2
UCEC	CCDC43 →	+0.483	+2.032	.002	.005	3	2
UCEC	NR2C2AP →	+0.385	+2.329	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,431 associations by consensus.

NDUFA6 by MFRP expression — UCEC

Explore this box plot interactively →