MFRP

Across TCGA patient cohorts, MFRP mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFRP-associated genes across cancer lineages are A-Raf_pS299, Notch1, and Caspase-7-cleavedD198. Each is linked with MFRP in more than 1 cancer types. Because this analysis shows association rather than direction, both MFRP-to-partner and partner-to-MFRP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by MFRP-low versus MFRP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFRP→partner) and Y-score (partner→MFRP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.118	-3.459	.011	.005	3	2
UCEC	Notch1 →	+0.201	+2.502	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.787	+2.502	<.001	.002	3	2
UCEC	C-Raf →	+0.154	+2.999	.006	.035	3	2
UCEC	Cyclin-B1 →	+0.618	+2.000	.005	.010	3	2
UCEC	eIF4G →	+0.336	+2.502	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

A-Raf_pS299 by MFRP expression — UCEC

Explore this box plot interactively →