MFN2

Across TCGA cell cohorts, MFN2 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MFN2-associated genes across cancer lineages are SNTG2, NKX2-6, and FAM236A. Each is linked with MFN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MFN2-to-partner and partner-to-MFN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNTG2 grouped by MFN2-low versus MFN2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFN2→partner) and Y-score (partner→MFN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SNTG2 →	+1.216	+3.754	<.001	.002	3	2
LUNG_NSCLC_LUAD	NKX2-6 →	+0.524	+2.637	<.001	.007	3	2
BLOOD_Leukemia	FAM236A →	+0.085	+3.684	<.001	<.001	3	2
URINARY_TRACT	CA5A →	+0.020	+5.087	<.001	.004	3	1
BLOOD_Leukemia	RFX4 →	+0.429	+3.807	<.001	.002	3	1
BLOOD_Leukemia	C6orf118 →	+0.034	+3.187	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

SNTG2 by MFN2 expression — BLOOD_Leukemia

Explore this box plot interactively →