MFF

Across TCGA patient cohorts, MFF mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MFF-associated genes across cancer lineages are ASNS, C-Raf, and 14-3-3_beta. Each is linked with MFF in more than 1 cancer types. Because this analysis shows association rather than direction, both MFF-to-partner and partner-to-MFF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MFF-low versus MFF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFF→partner) and Y-score (partner→MFF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.346	+2.321	.017	.033	3	2
UCEC	C-Raf →	+0.197	+2.321	<.001	.033	3	2
UCEC	14-3-3_beta →	-0.109	-3.295	.006	.009	3	1
UCEC	IGFBP2 →	-0.579	-2.999	.026	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.164	-2.321	.015	.034	3	1
UCEC	JNK2 →	+0.169	+3.026	.034	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ASNS by MFF expression — UCEC

Explore this box plot interactively →