MFF

Across TCGA pan-cancer cohorts, MFF RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated MFF data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MFF RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MFF expression acts as an unfavorable survival marker, although some lineages such as SKCM and LGG show a favorable association.

UVM, ACC, and LIHC are the cancer types where MFF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.427	0.754	<.001	126	view →
ACC	DFS	Median	All	0.347	0.801	<.001	101	view →
LIHC	OS	Tertile	All	0.675	0.834	<.001	77	view →
LUAD	OS	Tertile	All	0.599	0.757	<.001	62	view →
KIRP	DFS	Quartile	All	0.475	0.720	.001	48	view →
UCEC	DFS	Tertile	All	0.782	0.884	.003	32	view →
HNSC	OS	Median	All	0.473	0.727	<.001	27	view →
SCLC	DFS	Median	All	0.510	0.725	.012	21	view →
SKCM	OS	Median	All	0.391	0.256	.006	16	view →
LGG	OS	Tertile	All	0.651	0.437	.007	16	view →
KIRC	OS	Tertile	All	0.710	0.581	.025	14	view →
DLBC	OS	Tertile	II,III,IV	0.262	0.956	.011	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

MFF–UVM (DFS)

Open the UVM breakdown →