MFF

Across TCGA cell cohorts, MFF mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MFF-associated genes across cancer lineages are PRSS58, TPD52L3, and CABP5. Each is linked with MFF in more than 1 cancer types. Because this analysis shows association rather than direction, both MFF-to-partner and partner-to-MFF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by MFF-low versus MFF-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MFF→partner) and Y-score (partner→MFF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
LARGE_INTESTINE	TPD52L3 →	+0.056	+4.684	<.001	.002	3	1
BLOOD_Lymphoma	CABP5 →	+0.016	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PRSS58 by MFF expression — PANCREAS

Explore this box plot interactively →